Myocardial function recovery in peripartum cardiomyopathy: the role of global longitudinal strain and myocardial work - Scorecard - MDSpire
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Recovery of Myocardial Function in Peripartum Cardiomyopathy: Insights from Global Longitudinal Strain and Myocardial Work Analysis

  • By

  • Federica Ilardi

  • Federica Carusone

  • Dario D’Alconzo

  • Rachele Manzo

  • Alessia Palmentieri

  • Ciro Battaglia

  • Dalila Nappa

  • Giuseppe Giugliano

  • Raffaella Lombardi

  • Santo Dellegrottaglie

  • Viviana Narciso

  • Roberta Paolillo

  • Luca Bardi

  • Francesco S. Loffredo

  • Daniele Masarone

  • Enrica Pezzullo

  • Francesca Lanni

  • Donato Gerardi

  • Eugenio Stabile

  • Angelicarosa Cascone

  • Nouha Azaza

  • Giovanni Peretto

  • Giuseppe Bifulco

  • Attilio Di Spiezio Sardo

  • Gabriele Saccone

  • Alaide Chieffo

  • Cinzia Perrino

  • Giovanni Esposito

  • August 26, 2026

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Clinical Scorecard: Recovery of Myocardial Function in Peripartum Cardiomyopathy: Insights from Global Longitudinal Strain and Myocardial Work Analysis

At a Glance

CategoryDetail
ConditionPeripartum Cardiomyopathy (PPCM)
Key MechanismsLeft ventricular (LV) systolic dysfunction, global longitudinal strain (GLS), myocardial work (MW) indices
Target PopulationWomen diagnosed with PPCM, particularly those assessed at least 6 months post-acute phase
Care SettingEchocardiographic assessment in a multicentre observational registry

Key Highlights

  • PPCM is characterized by heart failure symptoms and reduced LVEF <45%.
  • Approximately 50% of women experience recovery of LVEF.
  • GLS and MW indices may reveal persistent myocardial impairment despite LVEF normalization.
  • 16 out of 22 women (72.7%) showed LV recovery.
  • Group A (<50% LVEF) exhibited significantly poorer GLS and MW parameters compared to controls.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of PPCM requires evidence of heart failure and reduced LVEF without other explanations.

Management

  • Monitoring and assessment of myocardial mechanics using GLS and MW indices are recommended.

Monitoring & Follow-up

  • Patients should be evaluated at least 6 months post-acute phase for myocardial performance.

Risks

  • PPCM carries substantial morbidity and mortality, with potential for subclinical systolic dysfunction.

Patient & Prescribing Data

Women with a history of PPCM or new PPCM diagnosis enrolled in a registry.

Echocardiographic measures provide insights into myocardial performance beyond conventional assessments.

Clinical Best Practices

  • Utilize GLS and MW indices for a comprehensive assessment of myocardial function in PPCM.
  • Ensure standardized echocardiographic protocols for accurate measurement.

Related Resources & Content

Original Source(s)

Myocardial function recovery in peripartum cardiomyopathy: the role of global longitudinal strain and myocardial work

  • by Federica Ilardi, Federica Carusone, Dario D’Alconzo, Rachele Manzo, Alessia Palmentieri, Ciro Battaglia, Dalila Nappa, Giuseppe Giugliano, Raffaella Lombardi, Santo Dellegrottaglie, Viviana Narciso, Roberta Paolillo, Luca Bardi, Francesco S. Loffredo, Daniele Masarone, Enrica Pezzullo, Francesca Lanni, Donato Gerardi, Eugenio Stabile, Angelicarosa Cascone, Nouha Azaza, Giovanni Peretto, Giuseppe Bifulco, Attilio Di Spiezio Sardo, Gabriele Saccone, Alaide Chieffo, Cinzia Perrino, Giovanni Esposito

  • August 26, 2026

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