Explainable AI in Cancer Imaging: Scoping Review of Methods, Modalities, and Clinical Integration - Scorecard - MDSpire

Explainable AI in Cancer Imaging: Scoping Review of Methods, Modalities, and Clinical Integration

  • By

  • Dimitris Fotopoulos

  • Ioannis Ladakis

  • Dimitrios Filos

  • Pedro A Moreno-Sánchez

  • Mark van Gils

  • Ioanna Chouvarda

  • May 20, 2026

  • 0 min

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Clinical Scorecard: A Comprehensive Review of Explainable AI Techniques in Cancer Imaging: Approaches, Technologies, and Clinical Application

At a Glance

CategoryDetail
Condition
Key MechanismsExplainable AI (xAI) enhances interpretability of AI decision-making processes in cancer diagnosis, utilizing techniques such as visualization tools and model-agnostic methods.
Target Population
Care Setting

Key Highlights

  • AI systems can improve diagnostic accuracy and reduce analysis time in cancer imaging.
  • The EU AI Act classifies AI systems for cancer diagnosis as 'high-risk', necessitating transparency and human oversight.
  • Explainable AI (xAI) aims to make AI decision-making processes transparent and understandable.
  • Clinical adoption of AI in cancer imaging requires workflow integration and staff training, including understanding AI outputs.
  • Validation of xAI methods in clinical settings is essential for trust and acceptance among clinicians, emphasizing the need for rigorous studies.

Guideline-Based Recommendations

Diagnosis

  • Utilize AI-based systems to predict tumor characteristics from imaging data.

Management

  • Implement xAI methods to support clinical decision-making and treatment planning.

Monitoring & Follow-up

  • Regularly evaluate the performance and interpretability of AI systems in clinical practice.

Risks

  • Address the black-box nature of AI models to enhance trust and adoption in clinical settings.

Patient & Prescribing Data

Patients with cancer undergoing imaging for diagnosis and treatment evaluation.

AI can assist in preoperative risk assessment and development of treatment plans.

Clinical Best Practices

  • Ensure AI systems are integrated into clinical workflows to facilitate adoption.
  • Provide training for staff on the use and interpretation of AI outputs, including interdisciplinary collaboration.
  • Conduct extensive validation of xAI methods in real-world clinical settings.

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