Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort - Scorecard - MDSpire
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Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort
Clinical Scorecard: Linkages Between Metal Mixtures in Seminal Plasma and Sperm Quality Metrics: An Exploratory Mediation Analysis of Urinary Oxidative Stress Markers in a Cross-Sectional Study from the RHCC-AC Preconception Cohort
At a Glance
Category
Detail
Condition
Sperm Quality Metrics
Key Mechanisms
Environmental metal exposure and oxidative stress
Target Population
Men from the Reproductive Health of Childbearing Couples–Anhui Cohort (RHCC-AC)
Care Setting
Cross-sectional cohort study
Key Highlights
Al positively associated with sperm abnormality rate.
Co and Cu inversely associated with progressive and total motility.
As, Fe, and Se positively associated with sperm concentration.
D,L-ortho-tyrosine mediates associations of Hg and V with sperm concentration.
Guideline-Based Recommendations
Diagnosis
Assess sperm quality parameters including concentration, motility, and morphology.
Management
Consider environmental metal exposure in male infertility evaluations.
Monitoring & Follow-up
Monitor oxidative stress biomarkers in relation to sperm quality.
Risks
Environmental and occupational exposures to metals may impair sperm quality.
Patient & Prescribing Data
Men experiencing infertility issues.
Clarify the role of oxidative stress in sperm quality through future studies.
Clinical Best Practices
Incorporate assessment of seminal plasma metal levels in infertility workups.
