Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash - Scorecard - MDSpire

Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash

  • By

  • Yun Li

  • Ning Wang

  • Junqi Hu

  • Changsheng Xie

  • Junchao Yang

  • Tingzhen Xu

  • June 4, 2026

  • 0 min

Share

Clinical Scorecard: Clinical Case: Adult-onset Still’s Disease Manifesting as Significant Hemorrhagic Pericardial Effusion in the Absence of Typical Rash

At a Glance

CategoryDetail
Condition
Key MechanismsAberrant activation of the innate immune system and excessive release of proinflammatory cytokines (IL-1, IL-6, IL-18) should be directly sourced.
Target Population
Care Setting

Key Highlights

  • treatment_insights

Guideline-Based Recommendations

Diagnosis

    Management

    • C
    • l
    • a
    • r
    • i
    • f
    • y
    • t
    • h
    • a
    • t
    • g
    • l
    • u
    • c
    • o
    • c
    • o
    • r
    • t
    • i
    • c
    • o
    • i
    • d
    • t
    • h
    • e
    • r
    • a
    • p
    • y
    • i
    • s
    • f
    • o
    • r
    • s
    • y
    • m
    • p
    • t
    • o
    • m
    • a
    • t
    • i
    • c
    • r
    • e
    • l
    • i
    • e
    • f
    • a
    • n
    • d
    • d
    • i
    • a
    • g
    • n
    • o
    • s
    • t
    • i
    • c
    • c
    • o
    • n
    • f
    • i
    • r
    • m
    • a
    • t
    • i
    • o
    • n
    • a
    • s
    • p
    • e
    • r
    • s
    • o
    • u
    • r
    • c
    • e
    • .

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Adults with suspected AOSD presenting with serositis.

        Glucocorticoids can lead to rapid defervescence and resolution of effusions.

        Clinical Best Practices

        • Consider AOSD in patients with unexplained serositis and systemic inflammation.
        • Perform comprehensive microbiological and cytological assessments to exclude other diagnoses.

        Related Resources & Content

        Original Source(s)

        Case Report: Adult-onset Still’s disease presenting with massive hemorrhagic pericardial effusion without the characteristic rash

        • by Yun Li, Ning Wang, Junqi Hu, Changsheng Xie, Junchao Yang, Tingzhen Xu

        • June 4, 2026

        Related Content

        Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause

        Depressive symptoms and risk of incident activities of daily living disability among older adults with symptomatic arthritis

        CAA Use Tied to Higher Arthroplasty Risk

        In a UK cohort, patients with osteoarthritis who initiated centrally acting analgesics had a higher hazard of knee or hip replacement than those who initiated SSRIs, though residual confounding by pain severity remains a key limitation.