The pathophysiological role of MiRNAs in heart failure
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By
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Kun Lian
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Qing Qi
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Lichong Meng
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Xin Zhu
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Yubin Zhang
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Yichang Xu
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Zhiguang Song
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Lin Li
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Siyuan Hu
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Zhixi Hu
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June 3, 2026
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Clinical Scorecard: The Role of MicroRNAs in the Pathophysiology of Heart Failure
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | MicroRNAs (miRNAs) regulate apoptosis, autophagy, myocardial fibrosis, inflammatory response, and energy metabolism in cardiomyocytes. |
| Target Population | |
| Care Setting | |
Key Highlights
- miRNAs are crucial regulators of gene expression in heart failure.
- They mediate cellular survival and death, impacting myocardial health.
- miRNAs inhibit pathological ventricular remodeling and fibrosis.
- They play a role in energy metabolism and inflammatory responses.
Guideline-Based Recommendations
Diagnosis
- Utilize natriuretic peptides and objective indicators of congestion for HF diagnosis.
Management
- Investigate the potential of circulating miRNAs as biomarkers.
Monitoring & Follow-up
- Further research is needed to confirm the diagnostic value of miRNAs.
Risks
- High prevalence, mortality, and healthcare costs associated with heart failure.
Patient & Prescribing Data
Patients with heart failure, including young adults and older adults.
The role of miRNAs in HF treatment is in early exploration and requires further clinical studies.
Clinical Best Practices
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