Malignant transformation of uterine serosal endometriosis to clear cell carcinoma in a postmenopausal patient: a rare case report
By
Xiaodong Mi
Tong Lin
Xiaogang Zhu
Qian Chen
Xihan Yang
Purun Zou
Dan Shu
Fei Tuo
June 17, 2026
Clinical Scorecard: Rare Case of Clear Cell Carcinoma Arising from Uterine Serosal Endometriosis in a Postmenopausal Woman
At a Glance
Category Detail
Condition Malignant transformation of endometriosis on the uterine serosa Key Mechanisms Malignant transformation of endometriosis on the uterine serosa Target Population Postmenopausal women Care Setting Hospital-based surgical intervention
Key Highlights
Malignant transformation of endometriosis is rare in postmenopausal women. The case involved a 62-year-old woman with a pelvic mass. Surgical intervention included total hysterectomy and bilateral adnexal resection. Postoperative pathology confirmed endometriosis with clear cell carcinoma transformation. No adjuvant chemotherapy was administered; patient remained under close follow-up with no abnormalities at six months. Guideline-Based Recommendations
Diagnosis
Utilize imaging studies such as ultrasound and CT scans to identify pelvic masses, with emphasis on their diagnostic roles. Management
Consider surgical intervention for suspected malignant transformation in endometriosis. Monitoring & Follow-up
Close follow-up is recommended post-surgery to monitor for recurrence. Risks
Increased risk of malignant transformation in postmenopausal women with endometriosis. Patient & Prescribing Data
Postmenopausal women with endometriosis
Surgical resection is the primary treatment for malignant transformation of endometriosis.
Clinical Best Practices
Early identification of endometriosis in postmenopausal women is crucial. Regular monitoring and follow-up for patients with endometriosis are recommended. Educate patients on symptoms indicating potential malignant transformation. Related Resources & Content
