Clinical Scorecard: Sex Differences Seen in Immune Cells
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Adults of European ancestry in the OneK1K cohort study.
Care Setting
Key Highlights
Men showed higher proportions of CD14-positive monocytes, dendritic cells, natural killer cells, proliferating natural killer cells, CD8-positive proliferating cells, effector memory T cells, and central memory T cells.
Women exhibited higher proportions of B cells, CD4-positive naive T cells, CD56-positive natural killer cells, and regulatory T cells.
Guideline-Based Recommendations
Diagnosis
Management
Tailor treatment approaches based on sex-specific immune profiles, considering specific therapies for autoimmune diseases.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Participants of European ancestry in the OneK1K cohort.
Sex-biased gene expression may influence treatment responses in autoimmune diseases.
Clinical Best Practices
Incorporate sex as a biological variable in immunological research.
Utilize single-cell RNA sequencing for detailed immune profiling.
Acknowledge the limitations of findings due to genetic homogeneity and single time-point sampling.
Consider hormonal factors when monitoring immune responses.
The approval was based on reduced proteinuria, and an ongoing trial is required to determine whether atacicept slows long-term kidney function decline.
