Open wide: a fresh look at periodontitis and atrial fibrillation
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By
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Julian S Haimovich
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Molly L Paras
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Shaan Khurshid
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December 9, 2025
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Clinical Scorecard: Exploring the Connection Between Periodontitis and Atrial Fibrillation
At a Glance
| Category | Detail |
| Condition | Atrial fibrillation (AF) and periodontitis |
| Key Mechanisms | Chronic inflammation, autoimmunity, bacterial dysbiosis leading to myocardial remodeling, atrial fibrosis, and electrophysiological disturbances |
| Target Population | Adults globally, particularly those with periodontitis and/or AF |
| Care Setting | Cardiology and dental care integrated settings |
Key Highlights
- Periodontitis is associated with a 33% higher risk of developing atrial fibrillation.
- Periodontal treatment in AF patients with severe periodontitis may reduce AF recurrence by 61% after ablation.
- Oral health should be incorporated into integrated AF care pathways alongside traditional cardiovascular risk factors.
Guideline-Based Recommendations
Diagnosis
- Consider assessment of oral health status in patients at risk for or with established AF.
Management
- Incorporate periodontal care and improved oral hygiene into comprehensive AF management plans.
- Collaborate closely between cardiologists and dentists to mitigate AF risk through oral health improvement.
Monitoring & Follow-up
- Monitor AF patients for oral health status and recurrence of AF post-ablation in relation to periodontal treatment.
Risks
- Recognize that periodontitis may contribute to systemic inflammation increasing AF risk and recurrence.
- Current evidence is mostly observational; causal relationship remains to be definitively established.
Patient & Prescribing Data
Patients with atrial fibrillation and/or periodontitis
Periodontal treatment is a low-risk, scalable intervention that may reduce AF recurrence and improve overall cardiovascular outcomes.
Clinical Best Practices
- Assess and address oral health as part of AF risk factor optimization.
- Promote interdisciplinary collaboration between cardiology and dental care providers.
- Encourage patients with AF to maintain good oral hygiene and seek periodontal care.
- Prioritize further high-quality prospective studies and clinical trials to clarify causal links and treatment benefits.
References