Association between preoperative neutrophil percentage-to-albumin ratio and survival outcomes in patients with colorectal cancer undergoing radical surgery: a retrospective study with external validation - Scorecard - MDSpire
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Link Between Preoperative Neutrophil-to-Albumin Ratio and Survival in Colorectal Cancer Patients Undergoing Radical Surgery: A Retrospective Analysis with External Validation
Clinical Scorecard: Link Between Preoperative Neutrophil-to-Albumin Ratio and Survival in Colorectal Cancer Patients Undergoing Radical Surgery: A Retrospective Analysis with External Validation
At a Glance
Category
Detail
Condition
Colorectal Cancer
Key Mechanisms
Neutrophil-to-Albumin Ratio (NPAR) as a marker of systemic inflammation and nutritional status.
Target Population
Patients with colorectal cancer undergoing radical surgery.
Care Setting
Oncology surgical units.
Key Highlights
Higher preoperative NPAR is associated with adverse clinicopathological features.
Each 1-SD increase in NPAR correlates with shorter overall survival (OS) and disease-free survival (DFS).
External validation showed consistent but attenuated associations for OS and DFS.
NPAR may serve as an adjunctive marker but has limited incremental predictive value beyond conventional factors.
Guideline-Based Recommendations
Diagnosis
Utilize NPAR in conjunction with traditional clinicopathological factors for risk stratification.
Management
Consider NPAR for assessing inflammatory and nutritional status in CRC patients preoperatively.
Monitoring & Follow-up
Monitor NPAR levels as part of routine preoperative assessments.
Risks
Be aware of the limitations of NPAR in predicting outcomes compared to established models.
Patient & Prescribing Data
Colorectal cancer patients undergoing radical surgery.
NPAR may indicate higher risk for postoperative complications and poorer outcomes.
Clinical Best Practices
Incorporate NPAR into preoperative assessments for CRC patients.
Use NPAR alongside established prognostic models for comprehensive evaluation.
