The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells
By
Lisa Isdraele Romano
Ilenia Aversa
Antonio Abatino
Costanza Maria Cristiani
Giulio Cesare Antico
Debora Gentile
Caterina Giordano
Emilio Straface
Michael Marrano
Elvira Angotti
Camillo Palmieri
Raffaella Gallo
Giuseppe Fiume
July 9, 2026
Clinical Scorecard: 1α,25-Dihydroxyvitamin D3 Influences T Cell Activation and Immune Checkpoint Mechanisms in Human T Cells
At a Glance
Category Detail
Condition Vitamin D modulation of T cell function Key Mechanisms Regulation of immune checkpoint pathways and T cell activation Target Population Healthy donors Care Setting In vitro analysis of human peripheral blood mononuclear cells
Key Highlights
1,25(OH)2 vitamin D reduces IFN-γ expression and secretion in CD8+ T cells. Increased PDCD1 and CTLA4 mRNA expression observed with vitamin D treatment. Selective modulation of CD8+ T cell activation markers at different vitamin D concentrations. No significant changes in IC molecules in CD4+ T cells. Vitamin D may regulate inflammatory T-cell responses under controlled conditions. Guideline-Based Recommendations
Diagnosis
No specific guidelines provided. Management
No specific guidelines provided. Monitoring & Follow-up
No specific guidelines provided. Risks
No specific guidelines provided. Patient & Prescribing Data
Healthy individuals with normal vitamin D levels
Vitamin D influences T cell effector function and immune checkpoint pathways.
Clinical Best Practices
Consider vitamin D levels in the context of immune modulation. Monitor T cell activation and checkpoint expression in patients receiving vitamin D. Related Resources & Content
