Testosterone Concentrations and Hypogonadal Symptoms in Swedish Males: Findings from the Vara – Skövde Cohort Prospective Study
By
Amar Osmancevic
Ying Li
Kristin Ottarsdottir
Margareta Hellgren
Ulf Lindblad
Matthew Allison
Penelope Trimpou
Spela Kokelj
Bledar Daka
July 17, 2026
Clinical Scorecard: Testosterone Concentrations and Hypogonadal Symptoms in Swedish Males: Findings from the Vara – Skövde Cohort Prospective Study
At a Glance
Category Detail
Condition Late-onset hypogonadism Key Mechanisms Association between endogenous testosterone levels and hypogonadal symptoms Target Population Community-dwelling men aged 30-74 years Care Setting Longitudinal study in southwestern Sweden
Key Highlights
Low total testosterone is associated with higher sexual symptom burden. No differences in AMS scores between intermediate and normal testosterone levels. Measurement method impacts testosterone values but not symptom burden. Longitudinal analysis shows baseline testosterone levels do not predict AMS scores after ten years. Guideline-Based Recommendations
Diagnosis
Utilize the Aging Male Symptom (AMS) questionnaire for symptom assessment. Management
Consider testosterone treatment in symptomatic men with low testosterone levels. Monitoring & Follow-up
Regularly assess testosterone levels and AMS scores in treated individuals. Risks
Increased diagnosis and treatment of testosterone deficiency may lead to overprescription. Patient & Prescribing Data
Men aged 30-74 years with potential testosterone deficiency symptoms.
Significant increase in testosterone prescriptions observed over the last two decades.
Clinical Best Practices
Employ standardized immunoassays for testosterone measurement. Assess both biochemical and symptomatic criteria for hypogonadism diagnosis. Related Resources & Content
