Single-cell immune landscape of the central nervous system of mice infected with rabies virus
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By
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Xinyue Wang
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Xinjie Zhang
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Wenwen He
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Xianzhu Xia
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Pingsen Zhao
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July 2, 2026
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Clinical Scorecard: Characterization of the Immune Cell Composition in the Central Nervous System of Mice Infected with Rabies Virus
At a Glance
| Category | Detail |
|---|
| Condition | Rabies Virus Infection |
| Key Mechanisms | Immune response variation between virulent CVS-11 and attenuated SRV9 strains. |
| Target Population | Mice infected with rabies virus strains. |
| Care Setting | Laboratory research on central nervous system immune responses. |
Key Highlights
- CVS-11 infection leads to dysfunctional immune responses.
- SRV9 infection is associated with protective immune features.
- Single-cell RNA sequencing reveals distinct immune cell activation states.
- Identification of signature genes linked to lethal RABV infection.
- Study provides insights for rabies vaccine design and immunotherapy.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable; study conducted on mice.
Insights into immune mechanisms may inform future vaccine strategies.
Clinical Best Practices
- Utilize single-cell RNA sequencing for detailed immune profiling.
- Consider immune response heterogeneity in rabies virus infections.
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