IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS - Scorecard - MDSpire

IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS

  • By

  • Veronica Buia

  • Cecilia Catellani

  • Stefania Croci

  • Beatrice Righi

  • Daria Morini

  • Angela Immacolata Falbo

  • Alessia Nicoli

  • Alessandro De Fanti

  • Lucia Belloni

  • Lorenzo Aguzzoli

  • Maria Teresa Villani

  • Chiara Sartori

  • Maria Elisabeth Street

  • June 5, 2026

  • 0 min

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Clinical Scorecard: Alterations in Follicular Fluid Levels of IGF-II, IGFBP-4, -6, -7, and HMGB1 in Patients with Polycystic Ovary Syndrome

At a Glance

CategoryDetail
Condition
Key MechanismsChronic low-grade inflammation, ovulatory dysfunction, hyperandrogenism, insulin resistance.
Target Population
Care Setting

Key Highlights

  • Lower levels of IGF-II and IGFBP-4 in PCOS compared to controls.
  • Increased levels of IGFBP-6 and IGFBP-7 in PCOS.
  • HMGB1 levels are elevated in the follicular fluid of PCOS patients.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of PCOS based on at least two of the following: hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology.

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Clinical Best Practices

          Related Resources & Content

          Original Source(s)

          IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS

          • by Veronica Buia, Cecilia Catellani, Stefania Croci, Beatrice Righi, Daria Morini, Angela Immacolata Falbo, Alessia Nicoli, Alessandro De Fanti, Lucia Belloni, Lorenzo Aguzzoli, Maria Teresa Villani, Chiara Sartori, Maria Elisabeth Street

          • June 5, 2026

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