Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease - Scorecard - MDSpire

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

  • By

  • Robin Schürfeld

  • Fabian Baalmann

  • Ekaterine Baratashvili

  • Benjamin Sandner

  • Anette Bachmann

  • Juliane Weiner

  • Marleen Würfel

  • Ralph Wendt

  • Martin Haussmann

  • Ingolf Bast

  • Joachim Beige

  • Joanna Kosacka

  • Nora Klöting

  • Knut Krohn

  • Toralf Kirsten

  • Ming-Zhi Zhang

  • Raymond C. Harris

  • Berend Isermann

  • Peter Kovacs

  • Matthias Blüher

  • Michael Stumvoll

  • Anke Tönjes

  • John T. Heiker

  • Thomas Ebert

  • July 7, 2026

  • 0 min

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Clinical Scorecard: Association of Serum Kallikrein-Related Peptidase 7 Levels with Renal Function and Mortality Risk in Chronic Kidney Disease Patients

At a Glance

CategoryDetail
ConditionChronic Kidney Disease (CKD)
Key MechanismsInversely associated with renal function and inflammation; potential link between renal function and cardiometabolic outcomes.
Target PopulationPatients with chronic kidney disease (CKD)
Care SettingNephrology outpatient care units

Key Highlights

  • Higher KLK7 levels are associated with lower estimated glomerular filtration rate (eGFR) and increased inflammation.
  • KLK7 independently predicts lower all-cause mortality in CKD patients.
  • A KLK7 threshold of 1383.6 pg/ml stratifies patients into low- and high-risk groups for mortality.
  • No significant associations were found between KLK7 levels and major adverse renal or cardiovascular events.

Guideline-Based Recommendations

Diagnosis

  • Assess renal function using estimated glomerular filtration rate (eGFR).
  • Evaluate inflammatory markers such as C-reactive protein (CRP).

Management

  • Monitor KLK7 levels as a potential biomarker for mortality risk in CKD patients.

Monitoring & Follow-up

  • Longitudinal follow-up of KLK7 levels and renal function over time.

Risks

  • Increased mortality risk associated with higher KLK7 levels.

Patient & Prescribing Data

Patients with chronic kidney disease (CKD) in the Leipzig-CKD cohort.

KLK7 levels may serve as a biomarker for assessing mortality risk and guiding management in CKD.

Clinical Best Practices

  • Incorporate KLK7 level assessment in routine evaluations of CKD patients.
  • Utilize KLK7 thresholds to stratify patients for targeted interventions.

Related Resources & Content

Original Source(s)

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

  • by Robin Schürfeld, Fabian Baalmann, Ekaterine Baratashvili, Benjamin Sandner, Anette Bachmann, Juliane Weiner, Marleen Würfel, Ralph Wendt, Martin Haussmann, Ingolf Bast, Joachim Beige, Joanna Kosacka, Nora Klöting, Knut Krohn, Toralf Kirsten, Ming-Zhi Zhang, Raymond C. Harris, Berend Isermann, Peter Kovacs, Matthias Blüher, Michael Stumvoll, Anke Tönjes, John T. Heiker, Thomas Ebert

  • July 7, 2026

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