Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis - Scorecard - MDSpire

Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis

  • By

  • Marta Seca

  • Jacek Gronwald

  • Tomasz Huzarski

  • Karen Glass

  • Amber Aeilts

  • Raymond H. Kim

  • Beth Karlan

  • Christian F. Singer

  • Andrea Eisen

  • Nadine Tung

  • Olufunmilayo Olopade

  • Louise Bordeleau

  • Pal Moller

  • William D. Foulkes

  • Susan L. Neuhausen

  • Fergus Couch

  • Tuya Pal

  • Robert Fruscio

  • Cezary Cybulski

  • Jan Lubinski

  • Shana Kim

  • Ping Sun

  • Steven A. Narod

  • Joanne Kotsopoulos

  • November 10, 2025

  • 0 min

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Clinical Scorecard: Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis

At a Glance

CategoryDetail
Condition
Key MechanismsImpact of fertility treatment on hormonal factors and potential breast cancer risk.
Target Population
Care Setting

Key Highlights

  • Study assesses infertility treatment impact on breast cancer risk in BRCA carriers, highlighting the need for further research.
  • No increased breast cancer risk associated with infertility treatment in the general population, but implications for BRCA carriers remain unclear.

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider fertility treatment options carefully in BRCA carriers, including genetic counseling.
    • Monitor hormonal treatments and their potential impacts, utilizing risk assessment tools.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Fertility medications include SERMs, gonadotropins, and progesterone; IVF is a common treatment. Monitor for potential side effects.

        Clinical Best Practices

        • Provide genetic counseling for BRCA carriers considering fertility treatment, emphasizing individualized treatment plans.
        • Incorporate patient history in treatment planning, considering genetic predisposition.

        References

        Original Source(s)

        Infertility Treatment and Breast Cancer Risk in Women with BRCA Pathogenic Variants: A Matched Case-Control Analysis

        • by Marta Seca, Jacek Gronwald, Tomasz Huzarski, Karen Glass, Amber Aeilts, Raymond H. Kim, Beth Karlan, Christian F. Singer, Andrea Eisen, Nadine Tung, Olufunmilayo Olopade, Louise Bordeleau, Pal Moller, William D. Foulkes, Susan L. Neuhausen, Fergus Couch, Tuya Pal, Robert Fruscio, Cezary Cybulski, Jan Lubinski, Shana Kim, Ping Sun, Steven A. Narod, Joanne Kotsopoulos

        • November 10, 2025

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