Association of the triglyceride–glucose index with albuminuria: a systematic review and meta-analysis
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By
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Ying-Yan Li
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Chun-Feng Deng
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Yi Zeng
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Xi Liu
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July 3, 2026
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Clinical Scorecard: Evaluation of the Relationship Between the Triglyceride-Glucose Index and Albuminuria: A Systematic Review and Meta-Analysis
At a Glance
| Category | Detail |
|---|
| Condition | Albuminuria |
| Key Mechanisms | Association with insulin resistance and renal microvascular injury. |
| Target Population | General population with varying risk factors for chronic kidney disease. |
| Care Setting | Clinical evaluation of renal risk factors. |
Key Highlights
- Higher TyG index significantly associated with albuminuria (OR = 2.37).
- Robust results maintained after excluding outlier studies.
- Subgroup analyses showed consistent positive correlations.
- Cohort study indicated increased risk of new-onset albuminuria with higher TyG index (HR = 1.19).
- TyG index may serve as a simple metabolic marker for early renal risk stratification.
Guideline-Based Recommendations
Diagnosis
- Use albuminuria as an early marker of glomerular microvascular injury.
Management
- Consider interventions targeting metabolic dysfunction to reduce albuminuria.
Monitoring & Follow-up
- Monitor TyG index as a potential indicator of renal risk.
Risks
- Elevated TyG index correlates with increased risk of renal injury and CKD progression.
Patient & Prescribing Data
Individuals at risk for chronic kidney disease, including those with insulin resistance.
Addressing metabolic disorders may mitigate albuminuria and renal risk.
Clinical Best Practices
- Assess TyG index in patients with risk factors for kidney disease.
- Incorporate albuminuria screening in routine evaluations for at-risk populations.
- Utilize TyG index as a cost-effective alternative for assessing insulin resistance.
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