Clinical Scorecard: Therapeutic Benefits of Smilax glabra (Tufuling) Formulations in Gout: A Comprehensive Systematic Review and Network Pharmacology Analysis

At a Glance

Key Highlights

• Tufuling-containing formulae associated with reduced pain and serum uric acid levels
• Lower incidence of gastrointestinal adverse events compared to Western medicine monotherapy
• Network pharmacology identified multiple active compounds and targets
• Key pathways involved include PI3K–Akt, TNF, and IL-17 signaling
• Further rigorous RCTs needed to validate long-term efficacy

Guideline-Based Recommendations

Diagnosis

• Diagnosis of gout based on clinical manifestations and serum uric acid levels

Management

• Use of Tufuling-containing formulae as adjunctive therapy for gout

Monitoring & Follow-up

• Monitor serum uric acid levels and clinical symptoms during treatment

Risks

• Incomplete reporting of adverse events and short follow-up periods

Patient & Prescribing Data

Individuals with gout, particularly those experiencing dampness-heat accumulation

Tufuling may enhance joint mobility and reduce inflammation

Clinical Best Practices

• Consider integrating Tufuling with other Chinese herbs and Western medicine
• Tailor dietary therapy to manage serum uric acid levels
• Monitor patients closely for adverse events and treatment efficacy

Related Resources & Content

• Systematic review registration