Therapeutic Benefits of Smilax glabra (Tufuling) Formulations in Gout: A Comprehensive Systematic Review and Network Pharmacology Analysis
By
Qiaoyun Liu
Xiuming Li
Yuping Lin
Xianyu Tang
Guanjie Fan
Lu Sun
July 1, 2026
Clinical Scorecard: Therapeutic Benefits of Smilax glabra (Tufuling) Formulations in Gout: A Comprehensive Systematic Review and Network Pharmacology Analysis
At a Glance
Category Detail
Condition Gout Key Mechanisms Dampness-heat accumulation, monosodium urate crystal deposition Target Population Patients with gout, particularly in China Care Setting Traditional Chinese medicine and Western medicine integration
Key Highlights
Tufuling-containing formulae associated with reduced pain and serum uric acid levels Lower incidence of gastrointestinal adverse events compared to Western medicine monotherapy Network pharmacology identified multiple active compounds and targets Key pathways involved include PI3K–Akt, TNF, and IL-17 signaling Further rigorous RCTs needed to validate long-term efficacy Guideline-Based Recommendations
Diagnosis
Diagnosis of gout based on clinical manifestations and serum uric acid levels Management
Use of Tufuling-containing formulae as adjunctive therapy for gout Monitoring & Follow-up
Monitor serum uric acid levels and clinical symptoms during treatment Risks
Incomplete reporting of adverse events and short follow-up periods Patient & Prescribing Data
Individuals with gout, particularly those experiencing dampness-heat accumulation
Tufuling may enhance joint mobility and reduce inflammation
Clinical Best Practices
Consider integrating Tufuling with other Chinese herbs and Western medicine Tailor dietary therapy to manage serum uric acid levels Monitor patients closely for adverse events and treatment efficacy Related Resources & Content
