Women’s risk of hypertension and cardiovascular disease subtypes by number of cycles of assisted reproductive technologies: a Norwegian registry-linkage study - Scorecard - MDSpire
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Women’s risk of hypertension and cardiovascular disease subtypes by number of cycles of assisted reproductive technologies: a Norwegian registry-linkage study
Clinical Scorecard: Association of Assisted Reproductive Technology Cycles with Hypertension and Cardiovascular Disease Risk in Women: Insights from a Norwegian Registry Study
At a Glance
Category
Detail
Condition
Hypertension and cardiovascular disease (CVD) risk
Key Mechanisms
Increased CVD risk primarily driven by thromboembolism (pulmonary embolism and deep vein thrombosis), possibly related to hormonal effects of ART and absence of corpus luteum in programmed frozen cycles
Target Population
Women born 1965-2000 in Norway undergoing assisted reproductive technology (ART) cycles
Care Setting
Population-based registry study with follow-up in primary and specialist healthcare settings
Key Highlights
Each additional ART cycle modestly increases CVD risk (HR 1.07), with no clear increased risk of hypertension.
Elevated CVD risk mainly driven by thromboembolic events such as pulmonary embolism and deep vein thrombosis.
Programmed frozen ART cycles are more strongly associated with increased CVD risk (HR 1.35).
Guideline-Based Recommendations
Diagnosis
Identify women undergoing ART cycles and monitor for cardiovascular risk factors.
Consider history of ART cycles, especially programmed frozen cycles, in cardiovascular risk assessment.
Management
Monitor cardiovascular health in women undergoing multiple ART cycles.
Focus on prevention and early detection of thromboembolic events in this population.
Monitoring & Follow-up
Long-term follow-up for cardiovascular disease, particularly thromboembolism, in women exposed to ART.
Regular assessment of blood pressure and cardiovascular risk factors post-ART treatment.
Risks
Increased risk of thromboembolism associated with ART, especially with multiple cycles and programmed frozen cycles.
No clear increased risk of chronic hypertension identified.
Patient & Prescribing Data
Women aged 20-45 years undergoing ART in Norway between 2004 and 2020
Risk of cardiovascular disease increases modestly with each additional ART cycle; programmed frozen cycles carry higher risk; no significant increase in hypertension risk observed.
Clinical Best Practices
Assess cardiovascular risk factors before and after ART treatment.
Provide counseling on potential thromboembolic risks associated with multiple ART cycles.
Implement cardiovascular monitoring protocols for women undergoing programmed frozen ART cycles.
Encourage lifestyle modifications to mitigate cardiovascular risk in women receiving ART.
