Preoperative and postoperative hospital care in abdominal surgery
Key Highlights
Firmicutes-dominated enterosignature (ES-Firm) is a significant risk factor for SSIs.
Prevotella-dominated enterosignature (ES-Prev) is associated with reduced SSI risk.
The Firmicutes-to-Prevotella ES ratio (ES-Firm-Prev ratio) is a robust, independent predictor of SSIs.
Guideline-Based Recommendations
Diagnosis
Use CDC criteria to diagnose SSIs within 30 days post-surgery, including superficial, deep incisional, and organ/space infections.
Management
Identify high-risk patients preoperatively using ES-Firm-Prev ratio to guide targeted preventive strategies.
Monitoring & Follow-up
Follow patients for 30 days postoperatively for SSI occurrence.
Monitor intestinal microbiota profiles preoperatively using 16S rRNA sequencing for risk stratification.
Risks
High ES-Firm-Prev ratio indicates increased risk of postoperative SSIs.
Disrupted intestinal microbiota may lead to bacterial translocation and infection.
Patient & Prescribing Data
133 patients undergoing elective abdominal surgery with preoperative rectal microbiota profiling
Preoperative microbiota profiling using enterosignatures can identify patients at higher risk for SSIs, potentially guiding prophylactic interventions.
Clinical Best Practices
Perform preoperative rectal swab sampling and 16S rRNA sequencing to determine enterosignatures.
Calculate ES-Firm-Prev ratio to stratify SSI risk before abdominal surgery.
Incorporate microbiota profiling into preoperative assessment to enhance SSI prevention strategies.
Maintain standard antiseptic measures alongside microbiota-based risk assessment.
