Wogonoside alleviates hyperosmotic stress-induced inflammation and apoptosis in human corneal epithelial cells via PI3K/AKT signaling - Scorecard - MDSpire
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Wogonoside Reduces Inflammation and Cell Death Induced by Hyperosmotic Stress in Human Corneal Epithelial Cells Through the PI3K/AKT Pathway

  • By

  • Yuan Zhong

  • Jian Shi

  • Xi Long

  • Xiyuan Liu

  • Lihao Chen

  • Jun Peng

  • Qinghua Peng

  • May 4, 2026

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Clinical Scorecard: Wogonoside Reduces Inflammation and Cell Death Induced by Hyperosmotic Stress in Human Corneal Epithelial Cells Through the PI3K/AKT Pathway

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients with moderate to severe dry eye-related epithelial injury.
Care Setting

Key Highlights

  • Wogonoside improves cell viability and reduces apoptosis in hyperosmotic stress conditions, highlighting its potential therapeutic role.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor inflammatory mediator levels, corneal epithelial cell health, and patient-reported outcomes.

      Risks

        Patient & Prescribing Data

        Wogonoside may provide anti-inflammatory and cytoprotective effects; monitor for potential ocular surface irritation.

        Clinical Best Practices

        • Integrate anti-inflammatory treatments such as corticosteroids or cyclosporine with ocular surface protection.

        Related Resources & Content

        Original Source(s)

        Wogonoside alleviates hyperosmotic stress-induced inflammation and apoptosis in human corneal epithelial cells via PI3K/AKT signaling

        • by Yuan Zhong, Jian Shi, Xi Long, Xiyuan Liu, Lihao Chen, Jun Peng, Qinghua Peng

        • May 4, 2026

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