Effect of preoperative tranexamic acid on hidden blood loss and C-reactive protein in patients undergoing Delta-channel endoscopic lumbar discectomy: a retrospective case-control study - Scorecard - MDSpire
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Effect of preoperative tranexamic acid on hidden blood loss and C-reactive protein in patients undergoing Delta-channel endoscopic lumbar discectomy: a retrospective case-control study
Clinical Scorecard: Influence of Intravenous Tranexamic Acid on Concealed Blood Loss and C-Reactive Protein Levels in Patients Undergoing Delta-Channel Endoscopic Lumbar Discectomy: A Retrospective Case-Control Analysis
At a Glance
Category
Detail
Condition
Lumbar Disc Herniation (LDH)
Key Mechanisms
Intravenous tranexamic acid (TXA) reduces hidden blood loss (HBL) without affecting C-reactive protein (CRP) levels.
Target Population
Patients undergoing Delta-channel interlaminar endoscopic discectomy for LDH.
Care Setting
Minimally invasive spinal surgery
Key Highlights
TXA administration significantly reduced HBL compared to control group.
No significant difference in CRP levels between TXA and control groups.
All surgeries were completed successfully with primary incision healing.
No incidents of lower extremity deep vein thrombosis (DVT) reported.
TXA, TT, and HCT identified as independent predictors of HBL.
Guideline-Based Recommendations
Diagnosis
Preoperative diagnosis of LDH confirmed.
Management
Administer 1 g TXA intravenously 15 minutes prior to surgery.
Monitoring & Follow-up
Monitor postoperative CRP levels to assess inflammatory response.
Risks
Consider potential for hidden blood loss during endoscopic procedures.
Patient & Prescribing Data
69 patients (37 males, 32 females) aged 17–78 years.
TXA is effective in reducing HBL without impacting CRP levels.
Clinical Best Practices
Utilize TXA in patients undergoing Delta-channel endoscopic discectomy to minimize HBL.
Ensure thorough preoperative assessment to exclude patients with contraindications.
