Endogenous Competition of circ_001024 for miR-145-3p: Implications for GLUT5 Regulation in Renal Cell Carcinoma
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By
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Lanlan Zhao
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Jieyu Xu
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Dandan Li
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Yao Chen
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Qingqing Fu
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Xiaorong Yang
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Jian Zhang
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November 5, 2025
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Clinical Scorecard: Endogenous Competition of circ_001024 for miR-145-3p: Implications for GLUT5 Regulation in Renal Cell Carcinoma
At a Glance
| Category | Detail |
|---|
| Condition | Renal Cell Carcinoma (RCC) |
| Key Mechanisms | Involvement of circRNA and miRNA interactions in RCC progression. |
| Target Population | Patients diagnosed with renal cell carcinoma. |
| Care Setting | Clinical and surgical settings for RCC treatment. |
Key Highlights
- Circ_001024 is significantly upregulated in RCC tissues.
- CircRNAs can act as miRNA sponges, influencing cancer progression.
- Surgical resection is the primary curative option for RCC.
- High-risk RCC patients face substantial recurrence and metastasis risks.
- Molecular markers for prognosis and treatment response are currently lacking.
Guideline-Based Recommendations
Diagnosis
- Histopathological diagnosis of RCC through tissue specimens.
Management
- Surgical resection as the primary treatment for RCC.
Monitoring & Follow-up
- Follow-up information for patients with complete clinicopathological data.
Risks
- High risk of recurrence and metastasis in advanced RCC cases.
Patient & Prescribing Data
Patients with histopathologically confirmed RCC.
Investigation into circRNA and miRNA interactions may lead to novel therapeutic targets.
Clinical Best Practices
- Utilize comprehensive molecular profiling for personalized treatment strategies.
- Ensure ethical clearance and proper patient selection criteria in clinical studies.
References
