The Dual Role of Macrophage Pyroptosis-Induced Cytokine Storms in Tumor Development
By
Qing-feng Wang
Hong-le Li
Hong Gao
Li-jiang Zhou
Yue Sun
Hao-ran Wang
Jia-yi Zhou
July 21, 2026
Clinical Scorecard: The Dual Role of Macrophage Pyroptosis-Induced Cytokine Storms in Tumor Development
At a Glance
Category Detail
Condition Macrophage Pyroptosis and Tumor Development Key Mechanisms Caspase-1 and caspase-4/5/11 pathways leading to GSDMD cleavage and cytokine release. Target Population Patients with tumor-associated macrophages (TAMs)-rich tumors. Care Setting Cancer immunotherapy and tumor microenvironment research.
Key Highlights
Pyroptosis triggers cytokine storms that can either promote anti-tumor immunity or tumorigenesis. Acute inflammatory responses activate anti-tumor immunity, while chronic responses support tumor progression. Pyroptosis-related biomarkers may aid in patient stratification and treatment-response prediction. Guideline-Based Recommendations
Diagnosis
Utilize pyroptosis-related biomarkers for patient stratification. Management
Consider NLRP3 inhibitors and IL-1β/IL-18 blockers in treatment strategies. Monitoring & Follow-up
Assess inflammatory cytokine profiles in patients. Risks
Chronic low-grade cytokine storms may lead to tumorigenesis. Patient & Prescribing Data
Patients with various cancer types exhibiting TAM-rich tumors.
Combination approaches with immune checkpoint inhibitors may enhance therapeutic outcomes.
Clinical Best Practices
Prioritize quantitative in vivo mapping of macrophage pyroptosis. Develop tumor-targeted pyroptosis inducers for precise treatment. Establish pyroptosis-based biomarker panels for clinical trials. Related Resources & Content
