Mobile Mpox Vaccination in New York City Provided Flexible Community-Responsive Vaccine Access During the 2022 Global Mpox Emergency

Category	Detail
Condition	Mpox (formerly monkeypox) outbreak in 2022
Key Mechanisms	Vaccination with JYNNEOS vaccine targeting high-risk LGBTQ+ sexual networks via mobile clinics at community venues
Target Population	LGBTQ+ individuals, especially men who have sex with men (MSM) involved in sexual networks and attendees of commercial sex venues, nightlife, and pride/health centers
Care Setting	Mobile vaccination clinics at commercial sex venues, nightlife establishments, pride centers, and health centers in New York City

3358 doses of JYNNEOS vaccine administered at 363 events across 58 NYC locations from August to November 2022
High vaccine uptake at commercial sex venues, with up to 60% of attendees vaccinated on site at some events
Mobile vaccination reduced racial and geographic disparities compared to nonmobile vaccination efforts

Surveillance and epidemiology conducted by NYC Department of Health and Mental Hygiene (DOHMH) during outbreak

Administration of 2 doses of JYNNEOS vaccine for full efficacy (66%-88%)
Use of mobile vaccination clinics to reach high-risk populations at venues where sexual networks converge
Community-led messaging to promote vaccine uptake and second dose completion

Tracking vaccine doses administered, demographics, and event attendance to evaluate uptake
Monitoring mpox case numbers in relation to venue reopening and vaccination efforts

Limited initial vaccine supply necessitated targeted vaccination strategies
Potential for mpox spread within highly connected sexual networks without vaccination and behavioral interventions

Primarily LGBTQ+ individuals, especially MSM attending commercial sex and nightlife venues in NYC

Two doses of JYNNEOS vaccine required for optimal protection; one dose provides partial efficacy; mobile vaccination facilitates access and equity

Engage community leaders and venue operators to build trust and facilitate on-site vaccination
Deploy mobile vaccination units to locations with high-risk populations to increase vaccine accessibility
Implement community-led messaging to encourage vaccination and adherence to two-dose schedule
Monitor vaccination coverage and mpox incidence to guide public health response
Prioritize vaccination in highly connected individuals within sexual networks to reduce transmission

Clinical Scorecard: Community-Driven Mobile Vaccination for Mpox in New York City During the 2022 Global Outbreak