From incidental positron emission uptake to in-vivo phenotyping: a short history of positron emission tomography in the study of atherosclerosis and the vulnerable plaque - Scorecard - MDSpire
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From incidental positron emission uptake to in-vivo phenotyping: a short history of positron emission tomography in the study of atherosclerosis and the vulnerable plaque
Clinical Scorecard: The Evolution of Positron Emission Tomography: From Incidental Uptake to In-Vivo Phenotyping in Atherosclerosis and Vulnerable Plaque Research
At a Glance
Category
Detail
Condition
Atherosclerosis
Key Mechanisms
Molecular imaging targeting pathobiological mechanisms such as macrophage activity, microcalcification, and angiogenesis.
Target Population
Patients with atherosclerosis and cardiovascular disease.
Care Setting
Clinical imaging and research settings.
Key Highlights
PET imaging has evolved to assess vascular biology and atherosclerosis.
18F-FDG is effective in detecting macrophage-rich inflammation.
18F-NaF can detect active microcalcification and high-risk plaques.
Emerging tracers target various biological processes in plaque biology.
PET's application in cardiovascular disease remains predominantly investigational.
Guideline-Based Recommendations
Diagnosis
Use FDG-PET to assess vascular inflammation and atherosclerosis.
Management
Consider novel PET tracers for phenotyping atherosclerotic plaques.
Monitoring & Follow-up
Monitor disease progression using PET imaging techniques.
Risks
Address technical hurdles and limitations of PET imaging for clinical translation.
Patient & Prescribing Data
Individuals with suspected or diagnosed atherosclerosis.
PET imaging can guide the understanding of plaque biology and risk stratification.
Clinical Best Practices
Utilize PET imaging for in-vivo assessment of atherosclerosis.
Incorporate emerging PET tracers in research to enhance understanding of plaque dynamics.
by Retesh Bajaj, Ming Young Simon Wan, Kris Thielemans, Eren Ozan Bakır, Soe Maung, Akash Sivananthan, Tom Crake, Anthony Mathur, Ryo Torii, Andreas Baumbach, Ashley Groves, Christos V. Bourantas
