Efficacy and safety of ozone autohemotherapy for zoster-associated pain: a meta-analysis and trial sequential analysis
By
Chunmei Wu
Zehao Liu
Yixin Zhang
Yangyang Li
Funing Liu
Yong Chen
Xiaojuan Liu
An Yang
Huide Wang
Qing Zhong
June 3, 2026
Clinical Scorecard: Assessment of the Safety and Effectiveness of Ozone Autohemotherapy for Pain Related to Herpes Zoster: A Meta-Analytical and Sequential Trial Review
At a Glance
Category Detail
Condition Key Mechanisms Anti-inflammatory and immunomodulatory effects. Target Population Care Setting
Key Highlights
Ozone autohemotherapy (O₃-AHT) reduces patient-reported pain scores. No significant difference in adverse reactions compared to control groups. Substantial heterogeneity exists among studies. GRADE evidence quality rating is very low to moderate. Guideline-Based Recommendations
Diagnosis
Management
Consider O₃-AHT for ZAP management if supported by further evidence. Monitoring & Follow-up
Risks
Patient & Prescribing Data
1,519 patients across 20 studies.
O₃-AHT may provide effective pain relief and improve quality of life without significant adverse effects.
Clinical Best Practices
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