Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience - Scorecard - MDSpire

Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience

  • By

  • Ashley Lu

  • Wei-Ting Chen

  • Maria Dalby

  • Diego Sainz Garcia

  • Marisa Vanheusden

  • Luuk E. de Vries

  • Veerle van Lieshout

  • Araks Martirosyan

  • Katleen Craessaerts

  • Sebastiaan Moonen

  • Magdalena Zielonka

  • Iordana Chrysidou

  • Anke Misbaer

  • Leen Wolfs

  • Benjamin Pavie

  • Dick Swaab

  • Dietmar Rudolf Thal

  • Inge Huitinga

  • Annemieke Rozemuller

  • Susan Karijn Rohde

  • Marc Hulsman

  • Henne Holstege

  • Rita Balice-Gordon

  • Niels Plath

  • Mark Fiers

  • Bart De Strooper

  • June 4, 2026

  • 0 min

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Clinical Scorecard: Transitions in Human Microglia at the Aβ–tau Intersection Relate to Different Pathways Leading to Dementia and Resilience

At a Glance

CategoryDetail
Condition
Key MechanismsMicroglial modulation at the Aβ–tau interface transition (needs citation)
Target Population
Care Setting

Key Highlights

  • Remove unsupported claims

Guideline-Based Recommendations

Diagnosis

    Management

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    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Older adults, specifically octogenarians and centenarians.

        Resilience mechanisms may provide insights for therapeutic targets.

        Clinical Best Practices

        • Incorporate spatial transcriptomics for detailed pathology assessment (needs citation)

        Related Resources & Content

        Original Source(s)

        Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience

        • by Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E. de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huitinga, Annemieke Rozemuller, Susan Karijn Rohde, Marc Hulsman, Henne Holstege, Rita Balice-Gordon, Niels Plath, Mark Fiers, Bart De Strooper

        • June 4, 2026

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