The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review - Scorecard - MDSpire
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Evaluating the Prognostic Significance of the Systemic Inflammatory Response Index (SIRI) in Patients with Acute Coronary Syndrome Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
Clinical Scorecard: Evaluating the Prognostic Significance of the Systemic Inflammatory Response Index (SIRI) in Patients with Acute Coronary Syndrome Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
SIRI reflects the balance between pro-inflammatory (neutrophils, monocytes) and anti-inflammatory (lymphocytes) responses influencing coronary lesion progression and cardiac remodeling
Target Population
Patients with ACS treated with primary PCI
Care Setting
Hospital and post-discharge cardiovascular care settings
Key Highlights
SIRI is a novel composite inflammatory biomarker calculated as neutrophil count × monocyte count / lymphocyte count
Elevated SIRI levels are associated with increased all-cause mortality and major adverse cardiovascular events (MACE) post-PCI
Inflammation plays a critical role in infarct expansion, plaque instability, and recurrent ischemic risk in ACS
Guideline-Based Recommendations
Diagnosis
Consider measuring SIRI as part of risk stratification in ACS patients undergoing PCI
Management
Use SIRI levels to identify high-risk patients for tailored post-PCI therapeutic strategies
Incorporate inflammation control as a secondary prevention target in CAD management
Monitoring & Follow-up
Monitor SIRI to assess residual inflammatory risk and guide long-term management post-PCI
Risks
High SIRI indicates increased pro-inflammatory activity linked to worse prognosis and higher risk of recurrent cardiovascular events
Patient & Prescribing Data
Patients with acute coronary syndrome treated with primary PCI
SIRI can help identify patients at higher risk of mortality and MACE, supporting individualized treatment and optimized post-discharge care
Clinical Best Practices
Integrate SIRI measurement into routine evaluation of ACS patients undergoing PCI for improved prognostic accuracy
Combine SIRI assessment with clinical and procedural factors to enhance risk stratification
Address residual inflammatory risk through targeted anti-inflammatory therapies alongside standard CAD treatments
by Chenming Hu, Qianling Ye, Shunjie You, Si Li, Christopher Dostal, Matthias Ernst, Francesco Paneni, Peter Pokreisz, Gabor Tamas Szabo, Attila Kiss, Bruno K. Podesser
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