Morphometric Assessment of Pancreatic Atrophy: A Quantitative Classification Utilizing CT and MRI Imaging Techniques in Istanbul
By
Fatih Öner Kaya
Esra Ümmühan Mermi
Alev Öztürk Günaldı
Haydar Kaan Karataş
Uğur Can Demir
Pınar Mert
Hüseyin Öztürk
Şule Sena Mazlum
Çağdaş Enginoğlu
April 22, 2026
Clinical Scorecard: Morphometric Assessment of Pancreatic Atrophy: A Quantitative Classification Utilizing CT and MRI Imaging Techniques in Istanbul
At a Glance
Category Detail
Condition Pancreatic Atrophy (PA) Key Mechanisms Progressive reduction in pancreatic parenchymal volume, acinar cell loss, fibrosis, and fatty infiltration. Target Population Individuals with chronic inflammatory diseases, metabolic disturbances, and physiological aging. Care Setting Radiology departments utilizing CT and MRI imaging.
Key Highlights
Introduction of the İstanbul Morphometric Pancreatic Atrophy Classification (IM-PAC) as a four-tier grading system. Significant association between IM-PAC grades and severity of ductal abnormalities and MRI-defined fibrosis. Excellent inter-observer agreement for thickness measurements (ICC = 0.89). Quantitative assessment improves reliability over subjective qualitative descriptions. Guideline-Based Recommendations
Diagnosis
Utilize IM-PAC for standardized assessment of pancreatic atrophy. Management
Integrate imaging findings with clinical features for comprehensive patient management. Monitoring & Follow-up
Regular follow-up imaging to assess progression of pancreatic atrophy. Risks
Consider risk factors such as age, sex, and metabolic disorders in evaluating pancreatic atrophy. Patient & Prescribing Data
Patients with chronic pancreatitis, diabetes, obesity, and other metabolic disorders.
Management strategies should address underlying causes of pancreatic atrophy and associated metabolic conditions.
Clinical Best Practices
Adopt quantitative imaging techniques for accurate assessment of pancreatic morphology. Ensure consistent use of IM-PAC grading in clinical practice to reduce inter-observer variability. References
