Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

Category	Detail
Condition	Emerging Mycotoxins Exposure
Key Mechanisms	Genotoxicity, oxidative stress, apoptosis, endocrine disruption
Target Population	General population exposed to food commodities
Care Setting	Food safety and toxicology assessment

Alternariol (AOH) and alternariol monomethyl ether (AME) are emerging mycotoxins with potential health risks.
AOH and AME exhibit genotoxic effects and may disrupt endocrine function.
Physiologically based kinetic (PBK) modeling predicts human exposure to AOH and AME.
Current regulations lack binding maximum levels for AOH and AME due to insufficient risk assessment data.
The study aims to provide a quantitative understanding of AOH and AME bioactivity for risk assessment.

Monitor concentrations of AOH and AME in food as per EU Commission Recommendation (EU) no. 2022/553.

Potential chronic dietary exposure to AOH and AME may exceed toxicological concern thresholds.

Individuals consuming food products potentially contaminated with AOH and AME.

No specific treatment insights provided; focus on exposure assessment.

Utilize PBK modeling for predicting internal concentrations of emerging mycotoxins.
Incorporate in vitro data to inform risk assessments for dietary exposure.

Clinical Scorecard: Physiologically Based Kinetic Modeling Predicts Human Internal Exposures to Alternariol and Its Monomethyl Ether Below In Vitro Toxicity Thresholds