Age-Dependent Decline of GPR68 and Calretinin-Positive Neurons in the Mucosal Layer of the Human Colon, Excluding the Myenteric Plexus - Scorecard - MDSpire
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Age-Dependent Decline of GPR68 and Calretinin-Positive Neurons in the Mucosal Layer of the Human Colon, Excluding the Myenteric Plexus
Clinical Scorecard: Age-Dependent Decline of GPR68 and Calretinin-Positive Neurons in the Mucosal Layer of the Human Colon, Excluding the Myenteric Plexus
At a Glance
Category
Detail
Condition
Age-related decline in GPR68 and calretinin-positive neurons in the colon
Key Mechanisms
GPR68 detects extracellular pH variations; calretinin-IR neurons are involved in enteric nervous system functions.
Target Population
Older adults (≥67 years) and younger adults (≤60 years)
Care Setting
Clinical settings involving lower bowel cancer resection
Key Highlights
GPR68 is widely expressed in the mucosa, circular muscle, and myenteric plexus of the colon.
Calretinin-IR neuron density declines in the mucosa of older adults.
No significant change in total PGP9.5-IR enteric neuronal fibers with age.
Ageing affects the density of calretinin-IR neurons specifically in the mucosal layer.
Potential implications for gastrointestinal disorders in older adults.
Guideline-Based Recommendations
Diagnosis
Consider age-related changes in enteric neuron populations when diagnosing gastrointestinal disorders.
Management
Monitor gastrointestinal function in older adults, especially regarding motility and sensory functions.
Monitoring & Follow-up
Assess for symptoms of constipation, fecal incontinence, and impaction in older patients.
Risks
Increased risk of gastrointestinal disorders due to structural changes in the enteric nervous system.
Patient & Prescribing Data
Older adults with potential gastrointestinal disorders.
Address dietary and fluid intake, and review medications affecting GI motility.
Clinical Best Practices
Utilize immunolabelling techniques to assess GPR68 and calretinin-IR neuron densities in clinical research.
Incorporate age-related physiological changes into treatment plans for older adults.
