Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART - Scorecard - MDSpire

Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART

  • By

  • Eeva Tortellini

  • Mariasilvia Guardiani

  • Anna Carraro

  • Lorenzo Ansaldo

  • Sara Corazza

  • Sara Giovanna De Maria

  • Silvia Garattini

  • Mirko Barresi

  • Valeria Belvisi

  • Maria Antonella Zingaropoli

  • Federica Dominelli

  • Carmen Falvino

  • Fabio Mengoni

  • Alessandro Tavelli

  • Cristina Giambi

  • Claudio Maria Mastroianni

  • Cosmo Del Borgo

  • Raffaella Marocco

  • Miriam Lichtner

  • December 24, 2025

  • 0 min

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Clinical Scorecard: Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART

At a Glance

CategoryDetail
ConditionHuman Papillomavirus (HPV) infection in individuals with HIV
Key MechanismsImmune response to HPV vaccination influenced by prior HPV infection and CD4 T-cell levels
Target PopulationPeople with HIV (PWH) undergoing antiretroviral therapy (ART)
Care SettingInfectious Diseases Unit, S.M Goretti Hospital, Latina, Italy

Key Highlights

  • Higher incidence of HPV-related cancers in PWH compared to HIV-uninfected individuals
  • Nonavalent HPV vaccine (Gardasil 9®) administered in a three-dose schedule
  • Significant correlation between CD4 T-cell count and immune response to vaccination
  • Stable antibody levels observed post-vaccination
  • Exclusion of participants with prior quadrivalent HPV vaccination or active chronic viral infections

Guideline-Based Recommendations

Diagnosis

  • Assess prior HPV infection through clinical documentation and HPV DNA tests

Management

  • Administer Gardasil 9® vaccine according to the Italian National Immunization Prevention Plan

Monitoring & Follow-up

  • Evaluate T-cell responses and seroconversion rates post-vaccination

Risks

  • Increased risk of HPV-related cancers in PWH with lower CD4 counts

Patient & Prescribing Data

Adults with HIV on ART

Vaccination is crucial for preventing HPV-related diseases in this population

Clinical Best Practices

  • Encourage vaccination in PWH regardless of age
  • Monitor CD4 T-cell counts to assess vaccine response potential
  • Provide education on HPV risks and vaccination benefits

References

Original Source(s)

Impact of Previous HPV Infection and CD4 T-Cell Levels on Immune Responses to a Three-Dose Nonavalent HPV Vaccine in Individuals with HIV Undergoing ART

  • by Eeva Tortellini, Mariasilvia Guardiani, Anna Carraro, Lorenzo Ansaldo, Sara Corazza, Sara Giovanna De Maria, Silvia Garattini, Mirko Barresi, Valeria Belvisi, Maria Antonella Zingaropoli, Federica Dominelli, Carmen Falvino, Fabio Mengoni, Alessandro Tavelli, Cristina Giambi, Claudio Maria Mastroianni, Cosmo Del Borgo, Raffaella Marocco, Miriam Lichtner

  • December 24, 2025

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