PFO closure in ischemic stroke: insights from a single-center real-world cohort - Scorecard - MDSpire

PFO closure in ischemic stroke: insights from a single-center real-world cohort

  • By

  • Felix Müller

  • Arda Civelek

  • Luis Weitbrecht

  • Lukas Badura

  • Kai Helge Schmidt

  • Florian Schlotter

  • Philipp Lurz

  • Stavros V. Konstantinides

  • Karsten Keller

  • Klaus Gröschel

  • Marianne Hahn

  • Timo Uphaus

  • May 8, 2026

  • 0 min

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Clinical Scorecard: Real-World Management of Ischemic Stroke Patients Undergoing PFO Closure: Findings from a Single-Center Cohort Study

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target Population
Care SettingRetrospective single-center cohort study at University Medical Centre Mainz.

Key Highlights

  • Clarify AS5F score significance in PFO closure outcomes.

Guideline-Based Recommendations

Diagnosis

  • Utilize RoPE and PASCAL scores for assessing PFO-related stroke risk.
  • Evaluate cryptogenic strokes in younger patients.

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        PFO closure may significantly reduce recurrent stroke risk compared to medical management alone; specific data on effectiveness should be included.

        Clinical Best Practices

        • Conduct thorough risk stratification using RoPE and PASCAL scores, while emphasizing individualized patient assessment.

        Related Resources & Content

        Original Source(s)

        PFO closure in ischemic stroke: insights from a single-center real-world cohort

        • by Felix Müller, Arda Civelek, Luis Weitbrecht, Lukas Badura, Kai Helge Schmidt, Florian Schlotter, Philipp Lurz, Stavros V. Konstantinides, Karsten Keller, Klaus Gröschel, Marianne Hahn, Timo Uphaus

        • May 8, 2026

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