Impact of Non-Invasive Brain Stimulation on Spontaneous Neural Activity in Patients with Post-Stroke Aphasia: A Protocol for a Coordinate-Based Meta-Analysis of fALFF Research - Scorecard - MDSpire

Impact of Non-Invasive Brain Stimulation on Spontaneous Neural Activity in Patients with Post-Stroke Aphasia: A Protocol for a Coordinate-Based Meta-Analysis of fALFF Research

  • By

  • Yao Rao

  • Jingjing Zhang

  • Jiawei Ni

  • Ming Zeng

  • Jiali Wu

  • Hui Xu

  • Zhiwei Zhao

  • Cong Wang

  • Chunlei Shan

  • April 22, 2026

  • 0 min

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Clinical Scorecard: Impact of Non-Invasive Brain Stimulation on Spontaneous Neural Activity in Patients with Post-Stroke Aphasia: A Protocol for a Coordinate-Based Meta-Analysis of fALFF Research

At a Glance

CategoryDetail
Condition
Key MechanismsNon-invasive brain stimulation (NIBS) including rTMS and tDCS to enhance language recovery, with fALFF as a biomarker for assessing effects.
Target Population
Care Setting

Key Highlights

  • NIBS shows promise as an adjunctive treatment for language recovery in PSA.
  • fALFF serves as a key biomarker for assessing spontaneous neuronal activity.
  • Meta-analysis aims to synthesize rs-fMRI data to understand NIBS effects on intrinsic neural activity.
  • Understanding the neural mechanisms behind NIBS effects is crucial for optimizing treatment.

Guideline-Based Recommendations

Diagnosis

  • Evaluate language impairments post-stroke using standardized assessments such as the Boston Diagnostic Aphasia Examination.

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        NIBS may improve language outcomes by modulating cortical excitability, particularly in the left hemisphere.

        Clinical Best Practices

        • Integrate NIBS with traditional speech language therapy, such as constraint-induced language therapy.
        • Utilize rs-fMRI to guide and evaluate treatment efficacy.

        References

        Original Source(s)

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