Prevalence of depression in patients with advanced cancer receiving palliative care: a meta-analysis of self‐report instruments - Scorecard - MDSpire

Prevalence of depression in patients with advanced cancer receiving palliative care: a meta-analysis of self‐report instruments

  • By

  • Han-Yu Deng

  • Min Li

  • Xu Xu

  • Qian-Qian Mou

  • June 24, 2026

  • 0 min

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Clinical Scorecard: Assessment of Depression Rates Among Advanced Cancer Patients Undergoing Palliative Care: A Meta-Analytical Review of Self-Reported Measures

At a Glance

CategoryDetail
ConditionDepression in advanced cancer patients
Key MechanismsPersistent low mood and loss of interest due to physical symptoms and existential distress
Target PopulationPatients with advanced cancer receiving palliative care
Care SettingPalliative care settings

Key Highlights

  • Pooled prevalence of depression in this population is 50.9%
  • Significant heterogeneity in prevalence estimates across studies
  • Depression is commonly under-recognized in advanced cancer patients
  • Standardized self-report scales are frequently used for assessment
  • Need for valid screening and care strategies to alleviate emotional distress

Guideline-Based Recommendations

Diagnosis

  • Use validated self-reported instruments to diagnose depression

Management

  • Implement screening and intervention strategies for depression

Monitoring & Follow-up

  • Regularly assess depression prevalence and patient well-being

Risks

  • Increased pain, reduced treatment adherence, impaired communication, decreased overall well-being

Patient & Prescribing Data

Patients with advanced cancer aged 18 and older

Depression screening is essential in palliative care to improve quality of life

Clinical Best Practices

  • Adopt suitable assessment tools for depression
  • Conduct subgroup analyses to understand prevalence variations
  • Ensure comprehensive care approaches that address emotional distress

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