Biomarker-guided immunomodulation in septic shock: navigating controversies and therapeutic implications for Critical Care
By
Yuxiu Dai
Hengyang Liu
Dingwen Xu
June 26, 2026
Clinical Scorecard: Immunomodulation Based on Biomarkers in Septic Shock: Addressing Controversies and Clinical Implications for Critical Care
At a Glance
Category Detail
Condition Septic Shock Key Mechanisms sTREM-1 as a predictor of mortality and kidney events Target Population ICU patients Care Setting Critical Care
Key Highlights
sTREM-1 predicts 90-day mortality and major adverse kidney events. Proposed thresholds for sTREM-1 vary significantly across studies. Static measurements of sTREM-1 may not capture the dynamic nature of critical illness. Longitudinal biomarker trajectories may better predict patient outcomes. Generalizability of sTREM-1 across diverse ICU populations is uncertain. Guideline-Based Recommendations
Diagnosis
Utilize sTREM-1 levels for risk stratification in septic shock. Management
Consider dynamic monitoring of sTREM-1 for tailoring interventions. Monitoring & Follow-up
Incorporate longitudinal sTREM-1 trends into patient management. Risks
Lack of standardized cutoff values for sTREM-1 may lead to misallocation of resources. Patient & Prescribing Data
Patients in critical care settings with septic shock.
sTREM-1 may indicate candidates for TREM-1 inhibition therapy.
Clinical Best Practices
Integrate sTREM-1 into multimodal platforms for better prognostication. Utilize continuous monitoring systems for real-time assessment of biomarkers. Related Resources & Content
