Oral microbiota alterations in radiographic axial spondyloarthritis
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By
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Aigerim Abuova
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Assel Meiramova
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Yekaterina Zueva
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Jeannette Kunz
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Laura Chulenbayeva
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Argul Issilbayeva
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Zharkyn Jarmukhanov
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Elizaveta Vinogradova
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Bayan Ainabekova
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Samat Kozhakhmetov
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Almagul Kushugulova
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May 12, 2026
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Clinical Scorecard: Changes in Oral Microbiome Among Patients with Radiographic Axial Spondyloarthritis
At a Glance
| Category | Detail |
|---|
| Condition | Radiographic Axial Spondyloarthritis (r-axSpA) |
| Key Mechanisms | Alterations in oral microbiome composition linked to systemic inflammation and disease progression. |
| Target Population | Patients with radiographic axial spondyloarthritis, predominantly males under 45. |
| Care Setting | Clinical research setting, observational cross-sectional study. |
Key Highlights
- Altered oral microbiome composition in r-axSpA patients compared to healthy controls.
- Increased abundance of key periodontal pathogens like Porphyromonas gingivalis and Actinomyces species.
- Associations between specific microbial taxa and disease severity, including sacroiliitis and ankylosis.
- Pro-inflammatory cytokines (e.g., IL-17) correlated with oral dysbiosis.
- Potential for oral microbiome as a biomarker or therapeutic target.
Guideline-Based Recommendations
Diagnosis
- Consider oral microbiome assessment in r-axSpA patients for potential biomarkers.
Management
- Monitor oral health and microbiome changes as part of comprehensive r-axSpA care.
Monitoring & Follow-up
- Evaluate associations between oral microbiome composition and systemic inflammation markers.
Risks
- Increased risk of periodontal disease in r-axSpA patients may exacerbate systemic inflammation.
Patient & Prescribing Data
Patients diagnosed with radiographic axial spondyloarthritis.
Oral dysbiosis may influence disease activity and should be considered in treatment strategies.
Clinical Best Practices
- Incorporate oral health assessments in routine evaluations of r-axSpA patients.
- Educate patients on the potential impact of oral microbiome on systemic inflammation.
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