Oral and gut microbiota dysbiosis with strengthened oral–gut connectivity in post-stroke cognitive impairment
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By
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Xuetong Zhang
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Fanping Chen
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Jie Yang
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Jiang Ma
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Xiaoyan Li
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Hui Wang
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Qing Li
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Yubin Zhao
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Jianchao Xu
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June 4, 2026
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Clinical Scorecard: Alterations in Oral and Gut Microbiota with Enhanced Oral-Gut Interaction in Cognitive Impairment Following Stroke
At a Glance
| Category | Detail |
|---|
| Condition | Post-stroke cognitive impairment (PSCI) |
| Key Mechanisms | Oral-gut axis interactions, dysbiosis of oral and gut microbiota |
| Target Population | Post-stroke patients, specifically those with cognitive impairment |
| Care Setting | Single-center clinical study |
Key Highlights
- PSCI associated with reduced oral richness and gut diversity
- Depletion of oral commensals and enrichment of opportunistic taxa observed
- Significant alterations in gut microbiota linked to cognitive impairment
- Stronger oral-gut association indicated by lower dissimilarity and higher oral enrichment score
- Combined oral-gut features showed favorable performance in exploratory tests
Guideline-Based Recommendations
Diagnosis
- Utilize MMSE and MoCA scores for cognitive assessment in PSCI
Management
- Consider microbiota profiling as part of PSCI evaluation
Monitoring & Follow-up
- Track changes in oral and gut microbiota in PSCI patients
Risks
- Monitor for potential cognitive decline linked to dysbiosis
Patient & Prescribing Data
133 post-stroke participants, 64 with PSCI
Focus on managing microbiota alterations to potentially influence cognitive outcomes
Clinical Best Practices
- Integrate microbiome analysis in the assessment of PSCI
- Monitor oral health as part of comprehensive care for stroke patients
- Consider the role of gut microbiota in cognitive rehabilitation strategies
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