Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET) - Scorecard - MDSpire
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Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

  • By

  • Stefanie Brehmer

  • Gustavo R. Sarria

  • Sara Würfel

  • Ardita Sulejmani

  • Frank Schneider

  • Sven Clausen

  • Yasser Abo-Madyan

  • Arne M. Ruder

  • Elena Sperk

  • Nima Etminan

  • Frank A. Giordano

  • May 28, 2026

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Clinical Scorecard: Prospective Phase II Trial Results of Intraoperative Radiotherapy Following Resection of Newly Diagnosed Brain Metastases in Adult Patients (INTRAMET)

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationAdult patients with newly diagnosed brain metastases, KPS ≥ 50, treatment-naïve, and anticipated gross total resection.
Care Setting

Key Highlights

  • The study aimed to enroll 50 patients to evaluate efficacy and safety of IORT, contributing to the evolving treatment landscape.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

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        Patient & Prescribing Data

        IORT is delivered immediately after tumor resection to improve local control, potentially reducing recurrence rates.

        Clinical Best Practices

        • Utilize preoperative MRI for treatment planning and neuronavigation.
        • Assess distances from the surgical cavity to critical structures intraoperatively.
        • Implement a structured postoperative care plan to monitor for complications.

        Related Resources & Content

        Original Source(s)

        Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)

        • by Stefanie Brehmer, Gustavo R. Sarria, Sara Würfel, Ardita Sulejmani, Frank Schneider, Sven Clausen, Yasser Abo-Madyan, Arne M. Ruder, Elena Sperk, Nima Etminan, Frank A. Giordano

        • May 28, 2026

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