Radiomics-Based AI for the Diagnosis and Prognosis of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis - Scorecard - MDSpire

Radiomics-Based AI for the Diagnosis and Prognosis of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis

  • By

  • Xuefeng Hua

  • Rongdang Fu

  • Ziwei Yin

  • July 2, 2026

  • 0 min

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Clinical Scorecard: AI-Driven Radiomics for Assessing Diagnosis and Prognosis of Tumor Cluster-Encapsulating Vessels in Hepatocellular Carcinoma: A Comprehensive Review and Meta-Analysis

At a Glance

CategoryDetail
ConditionHepatocellular carcinoma (HCC)
Key MechanismsVessels encapsulating tumor clusters (VETCs) as a poor prognostic factor; AI-based imaging for noninvasive prediction.
Target PopulationPatients with hepatocellular carcinoma.
Care SettingOncology and radiology departments utilizing imaging techniques.

Key Highlights

  • HCC accounts for approximately 90% of liver cancer cases.
  • VETC positivity is associated with higher recurrence rates and poorer survival.
  • AI technologies show potential for noninvasive prediction of VETC status.
  • Traditional diagnostic methods are invasive and subject to bias.
  • Existing studies show variability in AI model performance.

Guideline-Based Recommendations

Diagnosis

  • Utilize AI-based imaging techniques for predicting VETC status.

Management

  • Tailor treatment strategies based on VETC status.

Monitoring & Follow-up

  • Implement postoperative surveillance guided by VETC prediction.

Risks

  • Invasive methods may miss VETC-positive areas due to sampling bias.

Patient & Prescribing Data

Patients diagnosed with hepatocellular carcinoma.

Early identification of VETC status can influence management decisions.

Clinical Best Practices

  • Adhere to PRISMA-DTA guidelines for systematic reviews.
  • Integrate risk-of-bias appraisal and GRADE certainty ratings in evaluations.

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