Utilizing Intra- and Peritumoral Radiomics to Assess Ambiguous HER2 Status in Breast Cancer via Contrast-Enhanced Mammography
-
By
-
Cong Xu
-
Juan Qiu
-
Shijie Zhang
-
Yuqian Chen
-
Xiaodong Wang
-
Haicheng Zhang
-
Qi Wang
-
Tongpeng Chu
-
Ziyin Li
-
Peng Lu
-
Haizhu Xie
-
Heng Ma
-
Nina Qu
-
Ning Mao
-
Jing Liu
-
Runpeng Chen
-
Jing Gao
-
April 29, 2026
-
Clinical Scorecard: Utilizing Intra- and Peritumoral Radiomics to Assess Ambiguous HER2 Status in Breast Cancer via Contrast-Enhanced Mammography
At a Glance
| Category | Detail |
|---|
| Condition | Ambiguous HER2 Status in Breast Cancer |
| Key Mechanisms | Intra- and peritumoral radiomics features from contrast-enhanced mammography (CEM) |
| Target Population | Breast cancer patients with equivocal HER2 (IHC 2+) status |
| Care Setting | Clinical practice utilizing contrast-enhanced mammography |
Key Highlights
- Study involved 131 breast cancer patients with equivocal HER2 (IHC 2+) status.
- Nomogram achieved an AUC of 0.893 in the internal test cohort.
- Incorporated intratumoral and peritumoral radiomics signatures for predictive modeling.
- CEM provides a non-invasive method to predict HER2 status.
- Potential to reduce reliance on FISH testing for HER2 status confirmation.
Guideline-Based Recommendations
Diagnosis
- Utilize contrast-enhanced mammography for assessing HER2 status.
Management
- Incorporate radiomics features into clinical decision-making for HER2-positive breast cancer treatment.
Monitoring & Follow-up
- Monitor predictive performance of the nomogram through calibration curves and decision curve analysis.
Risks
- Consider the time and cost implications of additional FISH testing for equivocal HER2 status.
Patient & Prescribing Data
Breast cancer patients with equivocal HER2 (IHC 2+) status.
Timely identification of HER2 status is crucial for guiding treatment.
Clinical Best Practices
- Employ a nomogram that integrates radiomics and clinical factors for preoperative HER2 status prediction.
- Utilize CEM as a standard imaging technique in clinical practice.
References
