Clinical Scorecard: Predictive Value of Hematologic and Metabolic Markers for 28-Day Mortality in Patients with Sepsis: A Retrospective Study in an Intensive Care Setting

At a Glance

Key Highlights

• Hematological and metabolic indices are associated with 28-day mortality in sepsis.
• UA/Alb ratio showed the highest predictive performance (AUC: 0.968).
• TyG index and RAR also significantly associated with mortality.
• Non-survivors exhibited higher disease severity scores and distinct biochemical profiles.
• Independent predictors of mortality include UA/Alb ratio and SAPS II score.

Guideline-Based Recommendations

Diagnosis

• Utilize hematological and metabolic indices for early risk stratification in sepsis.

Management

• Focus on hemodynamic stabilization and continuous monitoring in septic patients.

Monitoring & Follow-up

• Regular assessment of hematological and metabolic biomarkers to predict outcomes.

Risks

• Increased mortality associated with elevated RDW, uric acid, triglycerides, and glucose levels.

Patient & Prescribing Data

805 adult patients with sepsis admitted to ICUs.

Early identification of high-risk patients is crucial for improving outcomes.

Clinical Best Practices

• Incorporate UA/Alb ratio in routine assessments for sepsis prognosis.
• Monitor metabolic indices like TyG index for risk assessment.
• Use established severity scores alongside novel biomarkers for comprehensive evaluation.

Related Resources & Content

• Study on hematologic and metabolic indices in sepsis