Giant solid pseudopapillary neoplasm of the pancreas in an adolescent girl: a case report with narrative review
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By
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Hang Zhou
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Jinqin Zha
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Yu Yang
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Yiwei Hou
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Chongyuan Chen
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Mingzheng Hu
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Rongchun Xing
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July 15, 2026
Clinical Scorecard: Case Report and Narrative Review of a Large Solid Pseudopapillary Neoplasm in an Adolescent Female Patient
At a Glance
| Category | Detail |
|---|
| Condition | Solid Pseudopapillary Neoplasm |
| Key Mechanisms | Rare epithelial tumor of the pancreas with low malignant potential, often presenting as a large mixed solid-cystic mass. |
| Target Population | Adolescent girls and young women |
| Care Setting | Multidisciplinary surgical assessment and management |
Key Highlights
- Solid pseudopapillary neoplasm (SPN) has a marked predilection for adolescent females.
- Giant tumors may complicate surgical planning due to vascular compression and hemorrhagic changes.
- Complete surgical resection usually results in favorable long-term outcomes.
- Immunohistochemistry supports the diagnosis of SPN.
- Postoperative care includes infection prevention strategies after splenectomy.
Guideline-Based Recommendations
Diagnosis
- Preoperative imaging and multidisciplinary assessment are crucial for diagnosis.
Management
- Laparoscopic distal pancreatectomy with splenectomy is recommended for giant SPN.
Monitoring & Follow-up
- Short-term follow-up is necessary to check for recurrence.
Risks
- Consideration of perioperative bleeding risk and oncologic safety is essential.
Patient & Prescribing Data
Adolescent female patients with solid pseudopapillary neoplasm.
Immunization planning and individualized antibiotic prophylaxis are recommended after splenectomy.
Clinical Best Practices
- Balance oncologic safety with organ preservation during surgical planning.
- Utilize imaging findings to guide preoperative diagnosis and surgical strategy.
- Implement long-term infection prevention measures post-splenectomy.
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