Virtual Brain Model Identifies Targeted Stimulation Sites for Altered Neural Activity in Tinnitus
By
Jiaqi Zhang
Shuting Han
Yongcong Shen
Xiaojuan Wu
Yunshu Zhao
Zijia Wu
Na Luo
Zhengyi Yang
Deying Li
Ming Song
Peng Wu
Duo-Duo Tao
Jisheng Liu
Yonggang Li
Tianzi Jiang
February 10, 2026
Clinical Scorecard: Virtual Brain Model Identifies Targeted Stimulation Sites for Altered Neural Activity in Tinnitus
At a Glance
Category Detail
Condition Key Mechanisms Altered neural activity in brain networks, modulated by rTMS and informed by DTB. Target Population Care Setting
Key Highlights
rTMS shows therapeutic benefits for tinnitus when targeting specific brain regions. Digital twin brain (DTB) model allows for simulation of brain stimulation effects. Study includes both acute and chronic tinnitus patients for comprehensive analysis. Innovative application of DTB in identifying effective stimulation sites. Guideline-Based Recommendations
Diagnosis
Management
Utilization of rTMS targeting auditory cortex and temporoparietal junction for therapeutic effects, administered over 2 weeks with ten sessions. Monitoring & Follow-up
Risks
Patient & Prescribing Data
rTMS therapy administered over 2 weeks with ten sessions, showing potential for symptom relief; outcomes measured include TFI scores.
Clinical Best Practices
Conduct thorough audiometric assessments to determine eligibility for rTMS. Utilize the TFI for evaluating the impact of tinnitus on patients' quality of life. Ensure right-handedness and absence of neurological disorders in participants for study consistency. Obtain informed consent and address ethical considerations in rTMS studies. References
