Efficacy differences and predictors of personalized mixed acoustic therapy in chronic tinnitus patients with and without hearing loss - Scorecard - MDSpire
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Comparative Efficacy and Predictive Factors of Customized Mixed Acoustic Therapy for Chronic Tinnitus in Patients with and without Hearing Impairment

  • By

  • Yuan Chen

  • Yue Ba

  • Meiling Sun

  • Jun Hu

  • Qin Jiang

  • Bin Liu

  • July 1, 2026

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Clinical Scorecard: Comparative Efficacy and Predictive Factors of Customized Mixed Acoustic Therapy for Chronic Tinnitus in Patients with and without Hearing Impairment

At a Glance

CategoryDetail
ConditionChronic Tinnitus
Key MechanismsPersonalized mixed acoustic therapy combining narrow-band noise and music.
Target PopulationPatients aged 40-60 years with chronic tinnitus, stratified by hearing loss status.
Care SettingProspective observational cohort study.

Key Highlights

  • Both HL and NHL groups showed comparable improvements in tinnitus frequency and loudness after 3 months.
  • NHL group had significantly greater reductions in HAMA and THI scores.
  • Independent predictors of favorable outcomes included NHL status, female sex, and lower baseline PSQI and HAMA scores.

Guideline-Based Recommendations

Diagnosis

  • Chronic subjective tinnitus diagnosed according to the 2014 clinical practice guideline of the American Academy of Otolaryngology–Head and Neck Surgery.

Management

  • Personalized mixed acoustic therapy as a non-invasive treatment option.

Monitoring & Follow-up

  • Regular assessment of tinnitus frequency, loudness, and psychological scales (HAMA, HAMD, PSQI, THI).

Risks

  • Exclusion of patients currently using psychotropic medication or participating in other interventional studies.

Patient & Prescribing Data

111 patients with chronic tinnitus (51 HL, 60 NHL).

Mixed acoustic therapy improves tinnitus perception and sleep quality, with greater psychological benefits in NHL patients.

Clinical Best Practices

  • Utilize bilateral subjective acoustic assessment for tinnitus evaluation.
  • Consider audiometric and psychometric phenotypes for personalized tinnitus management.

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