Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells - Scorecard - MDSpire

Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells

  • By

  • Jinsoo Kim

  • Qinghong Han

  • Shukuan Li

  • Byung Mo Kang

  • Yuta Miyashi

  • Tomoyuki Ishiguro

  • Michael Bouvet

  • Robert M. Hoffman

  • June 3, 2026

  • 0 min

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Clinical Scorecard: Comparative Analysis of the Effectiveness of Ivermectin and Five Standard Chemotherapeutic Agents Combined with Recombinant Methioninase on Human Colon Cancer Cells

At a Glance

CategoryDetail
Condition
Key MechanismsIvermectin and recombinant methioninase (rMETase) target methionine addiction in cancer cells.
Target Population
Care Setting

Key Highlights

  • Ivermectin combined with rMETase showed a chemosensitivity index (CI) of 6.7, significantly more effective than rMETase with 5-fluorouracil, cisplatinum, gemcitabine, and paclitaxel.
  • Doxorubicin combined with rMETase had a CI of 7.8, slightly more effective than the combination with ivermectin.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          HCT116 human colon-cancer cells.

          Clinical Best Practices

            Related Resources & Content

              Original Source(s)

              Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells

              • by Jinsoo Kim, Qinghong Han, Shukuan Li, Byung Mo Kang, Yuta Miyashi, Tomoyuki Ishiguro, Michael Bouvet, Robert M. Hoffman

              • June 3, 2026

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