Alterations in U12-Type RNA Splicing in Neutrophils of Systemic Lupus Erythematosus Patients
By
Luz P. Blanco
Binod Regmi
Carmelo Carmona-Rivera
Yudong Liu
Xiantao Wang
Philip M. Carlucci
Monica M. Jackson
Zerai Manna
Sarfaraz Hasni
Markus Hafner
Hong-Wei Sun
Mariana J. Kaplan
July 1, 2026
Clinical Scorecard: Alterations in U12-Type RNA Splicing in Neutrophils of Systemic Lupus Erythematosus Patients
At a Glance
Category Detail
Condition Systemic Lupus Erythematosus (SLE) Key Mechanisms Aberrant RNA splicing and impaired Nox activity in neutrophils Target Population Patients with Systemic Lupus Erythematosus Care Setting Clinical research and immunology
Key Highlights
Dysregulated alternative splicing affects immune genes in SLE. Impaired Nox activity linked to reduced CYBA expression in SLE neutrophils. U12-type intron retention observed in SLE low-density granulocytes. Guideline-Based Recommendations
Diagnosis
Patients must meet revised American College of Rheumatology criteria for SLE. Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Patients with systemic lupus erythematosus
Study identifies molecular mechanisms underlying neutrophil dysfunction.
Clinical Best Practices
Consider the role of aberrant RNA splicing in SLE pathogenesis. Monitor neutrophil function and Nox activity in SLE patients. Related Resources & Content
