Integrated systems toxicology identifies TCDD-responsive targets linked to immune dysregulation and treatment response in psoriasis - Scorecard - MDSpire
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Integrated systems toxicology identifies TCDD-responsive targets linked to immune dysregulation and treatment response in psoriasis
Clinical Scorecard: Comprehensive Toxicological Systems Approach Reveals TCDD-Responsive Targets Associated with Immune Dysfunction and Treatment Outcomes in Psoriasis
At a Glance
Category
Detail
Condition
Key Mechanisms
Dysregulation of the IL-23/IL-17 axis, TCDD exposure, immune dysfunction
Target Population
Care Setting
Key Highlights
Identification of 87 overlapping genes between TCDD-related targets and psoriasis-associated genes.
Core target genes LCK, MMP9, CXCR2, PTAFR, and CCNB1 show significant upregulation in psoriatic lesions.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Individuals with psoriasis, particularly those with moderate-to-severe forms.
Higher baseline MMP9 may indicate poorer clinical improvement in biologic therapy.
A VHA study across 11 vendors finds AI-generated primary care notes score lower than clinician-written notes, with the largest deficits in thoroughness, organization, and usefulness
