Programmed cell death mechanisms of traditional plant medicine in prostate cancer therapy
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By
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Yuchen Zhang
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Sheng Qin
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Yingping Wang
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Yajuan Xu
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Yanzhu Zhu
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July 14, 2026
Clinical Scorecard: Mechanisms of Programmed Cell Death Induced by Traditional Herbal Medicine in the Treatment of Prostate Cancer
At a Glance
| Category | Detail |
| Condition | Prostate Cancer |
| Key Mechanisms | Programmed cell death (PCD) including apoptosis, pyroptosis, autophagy, ferroptosis, and necroptosis. |
| Target Population | Males diagnosed with prostate cancer. |
| Care Setting | Research on alternative therapies for prostate cancer. |
Key Highlights
- Traditional plant medicine (TPM) induces multiple forms of programmed cell death (PCD) in prostate cancer.
- Key molecular targets include PI3K/AKT/mTOR, AMPK/mTOR pathways, and others.
- Current therapies for prostate cancer face challenges such as tumor resistance and recurrence.
Guideline-Based Recommendations
Diagnosis
- Diagnosis of prostate cancer should consider the prevalence and mortality rates globally.
Management
- Explore the use of traditional plant medicines as adjunctive therapies in prostate cancer treatment.
Monitoring & Follow-up
- Monitor the effects of TPM on various forms of programmed cell death in prostate cancer.
Risks
- Consider the limitations of current prostate cancer therapies, including treatment-related toxicities.
Patient & Prescribing Data
Men diagnosed with prostate cancer, particularly those with treatment resistance.
TPM has shown efficacy in overcoming chemotherapeutic resistance and inducing apoptosis.
Clinical Best Practices
- Investigate the role of PCD modulators in refining therapeutic strategies for prostate cancer.
- Focus on the interrelationships between different modes of cell death in the context of TPM.
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