Association of the new TyG indicator–TyHGB with prediabetes and diabetes in middle-aged and elderly postmenopausal women: a longitudinal study - Scorecard - MDSpire

Association of the new TyG indicator–TyHGB with prediabetes and diabetes in middle-aged and elderly postmenopausal women: a longitudinal study

  • By

  • Ziran Xiu

  • Zhengnan Gao

  • Lan Luo

  • Peiyang Yu

  • July 3, 2026

  • 0 min

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Clinical Scorecard: Linking the TyG Indicator—TyHGB with Prediabetes and Diabetes Risk in Middle-Aged and Elderly Postmenopausal Women: A Longitudinal Analysis

At a Glance

CategoryDetail
ConditionPrediabetes and Diabetes
Key MechanismsAssociation between TyHGB and dysglycemia in postmenopausal women
Target PopulationMiddle-aged and elderly postmenopausal women
Care SettingLongitudinal study assessing risk factors in community-dwelling women

Key Highlights

  • TyHGB significantly associated with increased risk of prediabetes and diabetes
  • Nonlinear dose-response relationship observed with TyHGB levels
  • Effective predictive value of TyHGB for diabetes in postmenopausal women
  • Study included 2,138 participants with normal glucose levels at baseline
  • Follow-up period of three years revealed 598 cases of prediabetes and 124 cases of diabetes

Guideline-Based Recommendations

Diagnosis

  • Evaluate TyHGB as a predictive marker for prediabetes and diabetes

Management

  • Consider TyHGB in risk assessment for diabetes in postmenopausal women

Monitoring & Follow-up

  • Regular monitoring of TyHGB levels in at-risk populations

Risks

  • Increased risk of diabetes associated with elevated TyHGB levels

Patient & Prescribing Data

Postmenopausal women with normal glucose tolerance

Focus on lipid management and monitoring glucose levels

Clinical Best Practices

  • Incorporate TyHGB in routine assessments for diabetes risk
  • Monitor lipid profiles alongside glucose levels in postmenopausal women

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